In aged patients, elimination of modafinil and its metabolites could possibly be lessened like a consequence of getting old. As a result, thought should be provided to the usage of decrease doses With this population (See Medical PHARMACOLOGY and Safety measures).

e., those who are weak metabolizers of debrisoquine; seven-ten% with the Caucasian population; similar or lower in other populations), the quantity of metabolism by CYP2C19 can be considerably enhanced. PROVIGIL might result in elevation of the levels of the tricyclics During this subset of patients [see DRUG INTERACTIONS].

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